Efficacy data from this study showed a median OS of 14.6 months (95% CI 13.8–15.3) and a median time to tumor progression of 7.8 months (95% CI 7.5–8.1). The disease control rate in patients with post-baseline evaluation was CB-839 in vivo 89%. The incidence of clinically significant (grade ≥3) adverse events of special interest (AESIs) was relatively low, and no new safety signals were reported. Phase IV studies offer the opportunity to mirror usual clinical practice, outside the limited populations and restrictions of phase III trials. In these pivotal trials of bevacizumab as first-line therapy in metastatic

NSCLC, most of the patients included in the analysis were of White (Caucasian) background. In the AVAiL trial,[5] only 5% of patients included in each arm were from Central/South America. Although the SAiL KPT-330 clinical trial trial[8] intended to describe a broad population, subjects from Hispanic

and African American backgrounds represented only 4% of the total population. Despite the approval of bevacizumab for treatment of NSCLC in most countries in Latin America, local experiences of efficacy and safety are diluted in the multitude of data from these studies. The recent publication of the Brazilian experience with breast cancer showed that outcomes in cancer treatment might differ from those reported in developed countries, and heterogeneity in QNZ datasheet chemotherapy use is among the reasons that could explain this fact.[9] Considering that lung cancer incidence and mortality continue to increase in Brazil, and that outcomes from use of an agent may differ between populations because of pharmacogenomics and particular clinical practice, analysis of regional experience might be essential for improvement of local

oncologic practice. Therefore, we undertook this retrospective review to determine the efficacy and safety of adding bevacizumab to first-line chemotherapy for non-squamous NSCLC in a Brazilian population. Methods Patients and Data Collection We identified all patients enough from the Sirio Libanes pharmacy registry (Sao Paulo, Brazil) who were treated for NSCLC with bevacizumab between July 2006 and January 2011. In total, 110 patients were identified, and 56 patients who met the following criteria were included in this report: patients were required to have non-squamous NSCLC tumor histology; to have received at least one cycle of first-line chemotherapy with addition of bevacizumab; and to have good quality follow-up data in their medical records, defined as the presence of a clinical description of toxicities that allowed for grading of adverse events according to the US National Cancer Institute’s Common Terminology Criteria for Adverse Events v3.0 (CTCAE),[10] and adequate registration of laboratory and image data. Patients with more than one primary tumor were excluded from the report.