(C) 2011 American Institute of Physics. [doi:10.1063/1.3615956]“
“Background and Aims: We investigated the behaviour of non-cholesterol sterols,
KPT-330 datasheet surrogate markers of cholesterol absorption (campesterol and sitosterol) and synthesis (lathosterol), in primary hyperlipemias.
Methods and results: We studied 53 patients with polygenic hypercholesterolemia (PH), 38 patients with familial combined hyperlipemia (FCH), and 19 age-and sex-matched healthy control subjects. In all participants, plasma sitosterol, campesterol and lathosterol were determined by gas chromatography coupled to mass spectrometry. To correct for the effect of plasma lipid levels, non-cholesterol sterol concentrations were adjusted for plasma BMS202 cholesterol (10(2) mu mol/mmol cholesterol). Patients with FCH were more frequently men, and had higher body mass index (BMI), fasting glucose, insulin and HOMA-IR. Lathosterol was higher in FCH than in pH or controls (p < 0.05). Campesterol was significantly lower in FCH (p < 0.05), while no differences were found between pH and controls. Sitosterol displayed higher values in pH compared to FCH (p < 0.001) and controls (p < 0.05). Spearman’s rank correlations showed positive correlations of lathosterol with BMI, waist circumference, HOMA-IR, triglycerides,
apoprotein B, and a negative one with HDL-cholesterol. Sitosterol had a negative correlation with BMI, waist circumference, HOMA-IR, triglycerides, and a positive one with HDL-cholesterol and buy GSI-IX apoprotein AI. Multivariate regression analyses showed that cholesterol absorption markers predicted higher HDL-cholesterol levels, while HOMA-IR was a negative predictor of sitosterol and BMI a positive predictor of lathosterol.
Conclusions: Our findings suggest the occurrence of an increased cholesterol synthesis in FCH, and an increased cholesterol absorption in pH. Markers of cholesterol synthesis cluster with clinical and laboratory markers of obesity and
insulin resistance. (C) 2010 Elsevier B.V. All rights reserved.”
“Paracetamol (PAR) crystals exhibit poor compressibility, poor flowability and its tablets show a tendency to cap. To improve the mechanical strength of tablets several kinds of “”Paracetamol for direct compression”" are present on the market. Current research demonstrated the best tablet properties with coated paracetamol (mass of tablets, diameter, height and mechanical strength, friability RSD < 2%). Furthermore, coated paracetamol in combination with both investigated superdisintegrants such as Vivasol(R) and Polyplasdone(R) XL-10 shows faster disintegration time and dissolution rate in comparison to paracetamol for direct compression.