After controlling these risk factors, neonatal sepsis remained

significantly associated with neuromotor development alterations at 12 months of corrected age. Children with sepsis were 2.5 times more likely to develop neuromotor developmental disorders when compared this website to those without sepsis (OR: 2.50; CI: 1.23‐5.10). It can be observed that BPD had borderline statistical significance for the association with neuromotor development alteration (OR: 2.06 CI: 0.97‐4.4). When considering confirmed sepsis as exposure separately, after adjustment for each of the possible confounding variables, the variables selected for the multivariate logistic model were BPD, PDA, and gestational age < 28 weeks. After controlling for these risk factors, confirmed sepsis was not associated with neuromotor development alterations (OR: 1.6 CI: 0.86‐3.17). Considering clinical sepsis as exposure, after controlling for risk factors, it remained significantly associated

with neuromotor development alterations (OR: 1.99; CI: 1.02‐3.9). In the bivariate analysis between the exposure variable (sepsis) and outcome (mental development), it was observed that children with sepsis were 1.9 times more likely to have MDI alterations than those without sepsis (CI: 1.05‐3.40). In the bivariate analysis, the variables confirmed sepsis (OR: 1.82; CI: 0.78‐4.24) and clinical sepsis (OR: 1.50; CI: 0.8‐2.78) were not associated with the outcome of MDI alteration. Regarding mental development, after adjusting for each of the possible confounding variables, the following variables were Dabrafenib manufacturer selected for multivariate logistic model: BPD, neonatal pneumonia,

and male gender. After controlling these risk factors, neonatal sepsis lost statistical significance and did not remain associated with mental development alterations at 12 months of corrected age (OR: 1.05; CI: 0.52‐2.14) (Table 4). The presence of an interaction between the confounders was not identified (Table 4). This study observed that preterm infants with very low birth weight that had neonatal sepsis are 2.5 times more likely to have altered neuromotor development at 12 months of corrected age, regardless of other risk factors, which supports Hydroxychloroquine some results found in the current literature. When analyzing the confirmed sepsis subgroup as a risk factor for neuromotor development alteration, after controlling for other confounding factors, the association lost statistical significance, perhaps due to the small number of confirmed cases. However, clinical sepsis showed to be an independent risk factor for neuromotor alteration. Other studies that also analyzed children with confirmed and clinical sepsis separately found conflicting results regarding the contribution of each of these groups. In a multicenter study of over 6,000 children, newborns with clinical sepsis had similar chances (OR: 1.6; CI: 1.3‐2.