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Sci U S A 2002,99(19):12391–12396.PubMedCentralPubMedCrossRef Competing interests The authors declare no competing interests. Authors’ contributions ACS, SDM, HDD designed the study; ACS, EAW, SLW, PS performed the work and interpreted molecular and genomic data; ACS, DWL developed molecular assays; ACS, DWL, RNZ, HDD, SDM analyzed epidemiological and evolutionary data and drafted the manuscript. All authors read and approved the final manuscript.”
“Background Cholera is an acute diarrheal disease caused by Vibrio cholerae that can be lethal within hours if left untreated. In 2011, a total of 589,854 cases were registered from 58 countries, including 7,816 deaths [1]. The severity, duration, and frequency of cholera epidemics appear to be increasing [2], indicating that cholera is a severe public health problem. In addition, V. cholerae is considered a category B bioterrorism agent by the CDC [3].