Some group x time effects NVP-BSK805 were observed among groups in low-density lipoprotein (LDL) levels (p = 0.005) with LDL levels significantly decreasing after the loading phase in the CrM group. However, values remained low and near baseline. Univariate ANOVA revealed no significant differences among groups in blood glucose (p = 0.67). Table 10 Serum lipids and glucose Marker N Group Day   Torin 1 nmr p-level       0 7 28     TCHL (mg/dl) 11 KA-L 149.1 ± 25 153.0 ± 23 149.9 ± 28 Group 0.91   12 KA-H 153.3 ± 26 152.3 ± 28 157.5 ± 22 Selleck MEK162 Time 0.15   12 CrM 156.3 ± 20 147.3 ± 19 158.9 ± 21 G x T 0.10 HDL (mg/dl) 11 KA-L 48.8 ± 11.3 51.0 ± 9.3 52.9 ± 11.4 Group 0.42   12 KA-H 53.0 ± 16.0 53.9 ± 18.4 53.6 ± 14.4

Time 0.03   12 CrM 45.6 ± 6.5 47.6 ± 7.3 48.5 ± 8.4 G x T 0.64 TCHL: HDL Ratio 11 KA-L 3.16 ± 0.7 3.09 ± 0.6 2.92 ± 0.7 Group 0.34   12 KA-H 3.03 ± 0.6 2.95 ± 0.5 3.04 ± 0.5 Time 0.04   12 CrM 3.48 ± 0.6 3.15 ± 0.6 3.36 ± 0.7 G x T 0.09 LDL 11 KA-L 83.4 ± 16* 86.5 ± 16 81.4 ± 18* Group 0.66 (mg/dl) 12 KA-H 79.4 ± 18* 82.7 ± 19 83.7 ± 16* Time 0.42   12 CrM 89.8 ± 20 81.4 ± 15† 92.5 ± 17 G x T 0.005 TRIG (mg/dl) 11 KA-L 84.5 ± 33 77.3 ± 30 78.5 ± 37 Group 0.20   12 KA-H 105.1 ± 37 78.4 ± 26 101.1 ± 27 Time 0.07   12 CrM 104.1 ± 28 92.1 ± 30 89.6 ± 30 G x T 0.45 Glucose (mg/dl) 11 KA-L 93.0 ± 5.1 90.5 ± 8.2 93.6 ± 4.7 Group 0.44   12 KA-H 91.1 ± 6.6 92.7 ± 8.1 90.4 ± 6.9 Time 0.57   12 CrM 90.5 ± 9.6 89.6 ± 5.5 88.3 ± 6.3 G x T 0.67 Values are means ± standard deviations. Lipid data were analyzed by MANOVA with repeated measures. Greenhouse-Geisser time and group x time (G x T) interaction p-levels are reported with univariate group p-levels. Glucose data were analyzed by repeated measures univariate ANOVA. † represents p < 0.05 difference from baseline. * represents p < 0.05 difference from CrM. Table 11 shows markers of catabolism

and bone status. Overall MANOVA revealed significant time (Wilks’ Lambda p < 0.001) effects with no significant group x time effects (Wilks’ Lambda p = 0.19) in markers of catabolism. Univariate MANOVA found no significant group x time interactions O-methylated flavonoid in blood urea nitrogen (BUN, p = 0.75), BUN to creatinine ratio (p = 0.24), aspartate aminotransferase (AST, p = 0.68), alanine aminotransferase (ALT, p = 0.48), total protein (p = 0.84), and total bilirubin (TBIL, p = 0.26). Serum creatinine levels increased in all groups (p < 0.001) over time with a significant group x time interaction demonstrating higher doses of creatine in the CrM and KA-H groups promoting significantly greater increases in serum creatinine (p = 0.03) than the KA-L group.