They found that the combination of normal renal volume and a renal flow index (renal flow divided by renal volume) below 1.5 mL/min per cm3 identifies PTA responders with the sensitivity of 91% and specificity of 67%. Duplex ultrasound has several advantages: it is widely available, non-invasive and inexpensive. The drawbacks

are: requirement of optimal sonographic test conditions, it is time-consuming, highly operator-dependent, limited by obesity and overlying intestinal gas and inconsistent in identifying accessory and aberrant renal arteries.31 Spiral CT angiography can reliably visualise accessory renal arteries and in this regard it is equal to conventional IA-DSA.17,18 It also provides better visualization of distal parts of renal arteries than does MRA and hence it is more accurate in the detection Lapatinib of RAS due to FMD.32 The diagnostic accuracy is reduced to some extent in patients with impaired renal function.33 The risk of contrast nephropathy seems to be the same with spiral CTA and conventional angiography.17 An important aspect of spiral CTA is the ability to visualize both arterial

lumen and arterial wall (which may contain calcified plaques). It also allows three-dimensional reconstruction, thus allowing spatial assessment of severity of stenosis.34,35 The major limitations of CE-MRA are overestimation of significance of moderate lesions and inter-observer variability. This is because the accuracy of interpretation NSC 683864 depends on the sophistication of image reconstruction software and radiologists’ skill in manipulating images using that software.36 At present there are no published studies that specifically investigate the utility of gadolinium-enhanced MRA for detection of FMD and there is little more than anecdotal data available from other studies. Although overt cases of FMD can be diagnosed with gadolinium-enhanced MRA, the general opinion is that it is currently not able to detect Afatinib order FMD with high accuracy in the

presence of only subtle anatomic changes.9 MRA, however, can be a useful procedure in patients with compromised renal function.37 It is contraindicated in patients with claustrophobia and metallic implants. In addition, among patients with moderate to severe renal disease (glomerular filtration rate <30 mL/min per 1.73 m2), and those requiring dialysis, administration of gadolinium has been strongly linked to nephrogenic systemic fibrosis.38,39 Two studies – RADISH14 (Renal Artery Diagnostic Imaging Study in Hypertension) and the diagnostic phase of DRASTIC40 (Dutch Renal Artery Stenosis Intervention Cooperative) study illustrate the pitfalls of diagnostic tests for RAS. In the RADISH study, the reported results of validity of CE-MRA and CTA were neither sufficiently reproducible nor sensitive enough to exclude RAS.