Table 2 Numbers of find more feature genes selected by 4 methods for each dataset Dataset PAM SDDA SLDA SCRDA 2-class lung cancer 7.98 422.74 407.83 118.72 Colon 25.72 65.67 117.08 214.87 Prostate 83.13
120.53 187.91 217.47 Multi-class lung cancer 45.26 57.98 97.27 1015.00 SRBCT 30.87 114.32 131.24 86.22 Brain 69.11 115.04 182.01 26.83 Performance comparison for methods based on different datasets The performance of the methods described above was compared by average test error using 10-fold cross validation. We ran 10 cycles of 10-fold cross validation. The average test errors were calculated based on the incorrectness of the classification of each testing samples. For example, for the 2-class lung cancer dataset, PKC412 solubility dmso using the LDA method based on PAM as the feature gene method, 30 samples out of 100 sample test sets were incorrectly classified, resulting in an average test error of 0.30. The significance of the performance difference between these methods was judged depending on whether or not their 95%
confidence intervals of accuracy overlapped. Here, if the upper limit was greater than 100%, it was treated ARRY-162 as 100%. Table 3 Average test error of LDA and its modification methods (10 cycles of 10-fold cross validation)
Dataset Gene selection methods Performance LDA PAM SDDA SLDA SCRDA 2-class Lung cancer data(n = 181, p = 12533, K = 2) PAM 0.30 0.26 0.15 0.16 0.42 SDDA 0.17 0.11 0.1 0.11 0.1 SLDA 0.47 0.3 0.3 0.3 0.32 SCRDA 0.73 0.20 0.19 0.17 ioxilan 0.19 Colon data(n = 62, p = 2000, K = 2) PAM 1.30 0.82 0.8 0.86 0.86 SDDA 2.25 2.09 1.33 1.29 1.25 SLDA 1.12 0.74 0.75 0.77 0.80 SCRDA 1.19 0.77 0.77 0.75 0.78 Prostate data(n = 102, p = 6033, K = 2) PAM 2.87 0.89 0.82 0.81 1.00 SDDA 2.53 0.71 0.72 0.68 0.74 SLDA 1.75 0.7 0.64 0.64 0.70 SCRDA 2.15 0.57 0.59 0.57 0.61 Multi-class lung cancer data(n = 66, p = 3171, K = 6) PAM 2.13 1.16 1.21 1.28 1.19 SDDA 1.62 1.32 1.32 1.31 1.30 SLDA 1.62 1.31 1.32 1.26 1.34 SCRDA 1.63 1.43 1.45 1.58 1.35 SRBCT data(n = 83, p = 2308, K = 4) PAM 0.17 0.01 0.01 0.03 0.01 SDDA 2.45 0.03 0.02 0 0.03 SLDA 2.87 0 0 0 0 SCRDA 2.32 0.03 0.03 0.02 0.03 Brain data(n = 38, p = 5597, K = 4) PAM 1.14 0.57 0.57 0.58 0.61 SDDA 1.09 0.61 0.62 0.63 0.55 SLDA 0.89 0.60 0.60 0.57 0.