Preventive strategies imposing a regulation of industrial production, even if fundamental, are not sufficient and need to be integrated along with other intervention addressed to make aware caregivers toward a proper surveillance of children. (C) 2012 Elsevier Ireland Ltd. All rights reserved.”
“Background: A possible contributing factor to the development of cognitive deficits in Alzheimer’s disease (AD) patients involves the exposure to early life stress. Objective: We explored the impact of stress on synaptic plasticity (long-term potentiation, LTP) of 6-month-old triple-transgenic mice (3xTg-AD). Methods: 3xTg-AD and control (NonTg) mice
were exposed to three stressors at the age of CH5424802 ic50 2 and 4 months. Excitatory postsynaptic potentials were recorded in the stratum radiatum of the CA1 region of hippocampal slices, in a two-pathway paradigm. Results: Slices taken
from 3xTg-AD mice exhibited significant deficits in LTP compared with NonTg slices. Early stress led to a further decrease in LIP in these mice, while BIX 01294 cost it did not affect NonTg mice. LIP in 3xTg-AD and stressed 3xTg-AD mice was rescued by pre-exposure to 0.2 mu m ryanodine. In an attempt to find a molecular correlate for the effects of stress in the 3xTg-AD mice, we found that stressed mice have an altered ratio of A beta 42/40 both in the cortex and hippocannpus. Conclusions: Stress experiences in young adults may accelerate the cognitive loss in AD mice, adding another dimension to the plethora of factors 4EGI-1 solubility dmso that lead to AD. (C) 2013 S. Karger AG, Basel”
“This study was conducted to determine the residues of isoproturon and its metabolites, 1-(4-isopropylphenyl)-3-methylurea, 1-(4-isopropylphenyl) urea, and 4-isopropylanilin in soil and mature earthworms under laboratory conditions. Mature earthworms (Aporrectodea caliginosa) were exposed for various durations (7, 15, 30, and 60 days) to soils contaminated with isoproturon concentrations
(2, 4, 6, 8, and 10 mg kg(-1) soil). The decrease in isoproturon concentration in the soil was inversely correlated to it’s initial concentration. The highest concentration detected for isoproturon in earthworms was observed during the first 15 days and decreased thereafter. Acute toxicity of isoproturon was investigated; total soluble protein content and glycogen of the worms were evaluated. Levels of these parameters were related to isoproturon concentration in soil and earthworms. No lethal effect of isoproturon was observed even at the concentration of 1200 mg kg(-1) soil after 60 days of exposure. A reduction of total soluble protein was observed in all treated worms (maximum 59.54%). This study suggests the use of the total soluble protein content and glycogen of earthworms as biomarkers of exposure to isoproturon. (c) 2008 Wiley Periodicals, Inc. Environ Toxicol 24: 396-403, 2009.