Methods: We conducted two phase 3 studies in treatment-naïve patients infected with HCV. In the NEUTRINO study, patients

with HCV GT 1, 4, 5, or 6 infection received open-label sofosbuvir 400 mg plus peginterferon alfa-2a 180 μg weekly and ribavirin 1000–1200 mg daily for 12 weeks. In the FISSION study, patients with HCV GT 2 or 3 infection were randomly assigned to www.selleckchem.com/products/3-methyladenine.html receive sofosbuvir 400 mg daily and ribavirin 1000–1200 mg daily for 12 weeks or peginterferon alfa-2a 180 μg weekly and ribavirin 800 mg for 24 weeks. The primary endpoint in both studies was the proportion of patients with a SVR 12 weeks after therapy. Results: In the NEUTRINO study, 327 patients (89% GT 1, 9% GT 4, <1% GT 5, and 2% GT 6) were enrolled and received study drug; 64% were male, 17% had compensated cirrhosis, and 29% carried the IL28B CC genotype. In the FISSION study, 256 patients (27% GT 2 and 71% GT 3) were randomized to receive

SOF +RBV and 243 (28% GT 2 and 72% GT 3) were randomized to receive PEG + RBV; Overall, 66% were male, 20% had compensated cirrhosis, and 43% carried the IL28B CC genotype. Rates of SVR12 are given in table.

Selleckchem Venetoclax One on-treatment breakthrough was observed in a SOF+RBV patient with documented non-adherence. No S282T was observed in patients with relapse. Sofosbuvir was generally well tolerated with lower rates of the most common find more adverse events – fatigue, headache, nausea, and insomnia – observed in patients receiving sofosbuvir and ribavirin than in those receiving peginterferon and ribavirin. Conclusions: Twelve weeks of sofosbuvir combination therapy was well tolerated and associated with high rates of SVR in treatment-naïve patients with HCV genotype 1–6 infection. Table 1. Outcomes Response NEUTRINO FISSION SOF+PEG+RBV for 12 wk SOF+RBV for 12 wk PEG+RBV for 24 wk (n = 327) (n = 253) (n = 243) VF = virologic failure; on-treatment virologic failure includes non-response and breakthrough W SIEVERT,1 M BUTI,2 K AGARWAL,3 Y HORSMANS,4 E JANCZEWSKA,5 S ZEUZEM,6 L NYBERG,7 RS BROWN JR.