J Med Chem 1996, 39:176–182.PubMedCrossRef 41. Abate C, Niso M, Contino M, Colabufo NA, Ferorelli S, Perrone R, Berardi F: 1-Cyclohexyl-4-(4-arylcyclohexyl)piperazines: Mixed sigma and human Delta(8)-Delta(7) sterol isomerase ligands
with antiproliferative and P-glycoprotein inhibitory activity. Chem Med Chem 2011, 6:73–80.PubMed 42. Abate C, Niso M, Lacivita E, Mosier PD, Toscano A, Perrone R: Analogues of sigma receptor ligand 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]pipe razine (PB28) with added polar functionality and reduced lipophilicity for potential use as positron emission tomography radiotracers. J Med Chem 2011, 54:1022–1032.PubMedCrossRef
43. Ivanova DNA Damage inhibitor S, Repnik U, Bojic L, Petelin A, Turk V, Turk B: Lysosomes in apoptosis. Methods Enzymol. 2008, 442:183–199. Competing interests No authors of this manuscript have any competing interests to disclose. Authors’ contributions JRH participated in the design and conduction of experiments, data analysis, and final drafting and writing of the manuscript. SV, RHM, CA, and FB all contributed new reagents selleckchem for these experiments. PG and DS were involved in research design and contributed to the drafting of the manuscript. WGH was closely involved in research design and drafting of the final manuscript. All authors read and approved the final manuscript”
“Background Most of the time, when patients have cancer in their bones, it is caused by metastatic cancer, or cancer that has spread from elsewhere in the body to the bones. It is much less
common to have a primary bone cancer that arises from cells that make up the bone. Surgery, chemotherapy and radiation therapy are the three main types of treatment for bone cancer. Unfortunately, there are risks and side effects associated with each of the treatments for bone cancer. The main risks associated with surgery include infection, recurrence of the cancer, and injury to the surrounding tissues that may cause loss of sensation, strength or function, CYTH4 or even cause amputation. The medications of chemotherapy are designed to kill rapidly dividing or growing cells, but unfortunately normal cells are also adversely affected. Radiation therapy damages the surrounding skin and soft tissue and impairs wound healing. There has been much recent advancement in the understanding and treatment of bone cancer. This has led to more focused radiation therapy to reduce the risk to surrounding tissues, less side effects, and improved treatment options, including limb-salvaging surgery, that decrease the need for amputation. There is currently much work being conducted in each of these areas as well as investigations into the mechanisms of development of metastatic cancer.