It is expected that these new technologies will facilitate safer, more sensitive and accurate prenatal diagnostic tests in the near future. In this review, we highlight the most recent advances in methods for NIPD of aneuploidies, and GSK690693 research buy we discuss their future implications in clinical practice.”
“Aim: To study the relationship between cervical
lengths measured by ultrasound and risk of preterm delivery.
Material & Methods: We examined 209 women with singleton pregnancies. The inclusion criteria were women who presented with regular and painful contractions (>= 2 contractions at intervals of 10 min for at least 1 h). Transvaginal scan was performed to measure the cervical length. The clinical management of the women, including hospitalization and administration of tocolytics, was determined by the attending obstetricians, who were blinded about cervical length. selleck chemical The primary outcome was delivery within 7 days of presentation.
Results: Delivery within 7 days of presentation occurred in 19/209 (9%) of pregnancies who were presenting with regular and painful uterine contraction at 31 weeks
of gestation, and this was inversely related to cervical length. Logistic regression analysis demonstrated that cervical length and history of abortion remain as significant contributors to predicting delivery within 7 days. Of the patients who presented with threatened preterm labor, 117 (56%) received tocolytics, and 92 (44%) did not. In the group with a cervical length of <15 mm, delivery selleck inhibitor within 7 days occurred in 15/21 (71.4%) who were treated with tocolytics and 2/5 (40%) that were managed expectantly.
Conclusion: Women with threatened preterm labor and a cervical length of <15 mm at presentation are at high risk of delivering preterm within 7 days. Sonographic measurement of cervical length helps to avoid over-diagnosis of preterm
labor.”
“Objective: To investigate cortisol responses to adrenocorticotropic hormone during thyrotoxic (G1) and euthyroid (G2) phases in patients with Graves disease (GD) who were without adrenal autoimmunity.
Methods: Fifteen patients with GD, who were thyrotropin receptor antibody positive and 21-hydroxylase antibody negative, were recruited to this prospective pilot study. A modified short Synacthen test (SST) was performed, in which cortisol was measured every 30 minutes for 2 hours during G1 and G2.
Results: The median times to SST were 3 weeks (G1) and 27 weeks (G2) after diagnosis of GD. Integrated stimulated cortisol levels were significantly lower at G1 in comparison with G2: mean +/- standard error of the mean for area under the curve was 78,091.6 +/- 4,462.1 nmol/L (G1) versus 89,055 +/- 4,434 nmol/L at 120 minutes (G2),, P=.017; and for delta area under the curve was 36,309.9 +/- 3,526 nmol/L (G1) versus 44,041.7 +/- 2,147 nmol/L at 120 minutes (G2), P=.039.