However, identification of eloquent areas not only failed to eliminate but rather increased the risk of postoperative deficits, likely indicating close proximity of functional cortex to tumor.”
“OBJECTIVE: In patients with temporal lobe epilepsy, invasive electroencephalographic study has shown that epileptic activities arising from the unilateral temporal lobe often propagate to the contralateral temporal lobe. Which commissural pathways are responsible for this spreading remains controversial. Some previous studies, however, have suggested that interhemispheric
connections between bilateral basal temporal regions (BTR) might have a significant role in propagation of epileptic activities.
METHODS: We attempted to elucidate the neural Transmembrane Transporters inhibitor connections LY2835219 research buy between bilateral BTRs using the cortico-cortical evoked potential (CCEP) method. Five consecutive patients with temporal lobe epilepsy who underwent intracranial
electroencephalographic monitoring were studied.
RESULTS: CCEP responses were recorded from a total of 24 electrodes after stimulation of the contralateral BTRs (24 CCEPs/720 recordings; 3.33%). There were 3 types of CCEP waveform: type N-P (16 of 24; 66.7%) consisting of an initial negative peak followed by a positive peak; type N (4 of 24; 16.7%) showing a negative peak only, and type P (4 of 24; 16.7%) showing a positive peak GSK126 datasheet only. The latencies ranged from 48.2 to 102.3 ms (mean, 65.5 ms) for negative peaks and 70.2 to 122.0 ms (mean, 95.2 ms) for positive peaks. In all patients, the basal temporal language area was associated with at least 1 CCEP, either as a stimulated region or a recorded region (11 of 24; 45.8%).
CONCLUSION: These data indicate that there is a neural connection between bilateral BTRs. In consideration of the involvement of the basal temporal language area, we speculate that these responses may reflect some physiological connections between bilateral BTRs.”
“OBJECTIVE: To determine the clinical value of motor functional magnetic resonance imaging
(fMRI) in the presurgical evaluation of a large group of children and adolescents with epilepsy caused by lesions close to the central sulcus.
METHODS: Forty-three patients (19 males; mean age, 13 years) with lesional focal epilepsy underwent motor fMRI as part of a multidisciplinary standardized presurgical evaluation between 2000 and 2006. fMRI data were analyzed using statistical parametric mapping (SPM2) and screened for the presence of movement-related artifacts. The ways in which the results of motor fMRI influenced the decision-making process were reviewed.
RESULTS:The success rate of motor fMRI was 93% and data were of high quality in 67.5% of the patients. Together with other clinical considerations, motor fMRI results contributed to the surgical management of 32 patients (74%).