Furthermore the prognosis is worse for the patients with advanced stages of disease and late diagnosis, as they are usually older, uncollaborative, bed-bound at admission and affected by several comorbidities (> 2). In opposition prognosis is more favourable in younger patients affected by minor comorbidities (< or = 2), being the diagnosis easier to achieve

in these cases. Although the data from our case series show that the Hartmann’s procedure is associated with a higher postoperative mortality (57% in obstructed patients and 41% in the patients affected by subocclusion) than the intestinal A-769662 datasheet derotation with colopexy (0% in both groups of patients), we do not retain that it represents an unsuccessful prognostic factor itself.

Indeed this procedure is associated with an unfavourable prognosis as it is mostly performed in severe cases which are often associated with intestinal sigmoid necrosis. The abdominal X-ray may show unspecific signs of sigmoid volvulus, but it is not able to offer an etiologic diagnosis. Indeed in 30-40% of the cases the abdominal X-ray is not diagnostic for sigmoid volvulus [16] because the transverse colon or small bowel distension can superimpose upon the sigmoid loops. Furthermore a redundant transverse colon or an obstructed small bowel loop may mimic a sigmoid volvulus [17, 18]. Conversely CT scan allows to achieve a diagnosis even in the indeterminate cases [19–21] being particularly useful in the patients affected by intestinal subocclusion with ambiguous and insidious www.selleck.co.jp/products/azd9291.html clinical onset and progression, and allowing an earlier

diagnosis CYC202 chemical structure with a lower mortality. The main limitation of this series is due to the fact that we analyzed patients with sigmoid volvulus treated with emergency surgery, while we excluded the majority of them being managed successfully with PS-341 in vitro medical therapy; we also included patients in an advanced disease stage (ischemia/peritonitis). Therefore the advanced disease stage, the treatment performed in emergency and the elderly age of our population with a poor functional status could justify the high mortality rate that was detected. Conclusions The mortality of patients with sigmoid volvulus treated surgically is closely related to the disease stage, a prompt surgical timing, the patient functional status and his collaboration with clinicians in order to define a correct diagnosis and treatment. For this reason mortality is higher in both obstructed patients with generalized peritonitis and patients affected by subocclusion with late diagnosis and undergoing surgery in advanced stages; in both cases an emergency Hartmann’s procedure (57% and 50% mortality rate respectively) is to be considered. However in both patients groups an early management is crucial in order to avoid necrosis of the twisted loop and the consequent mortality increase.