For DCGF, there appears to be no difference in cumulative incidences. In intermediate-risk recipients, for both DFG and DCGF, the cumulative incidences differ from 5 years post-transplant, although there was a lesser difference in DCGF. In the unadjusted

and adjusted models of low- and intermediate-risk recipients, Forskolin mouse there was no association between IL-2Ra and patient survival (Tables 2,3). For low-risk recipients, donor and recipient characteristics associated with increased patient death include deceased-donor transplant, older recipients, diabetes, smokers and recipients with cardiovascular disease, whereas for intermediate-risk recipients, older donors and recipients, diabetes, longer duration of dialysis (>3 years) and recipients with cardiovascular disease were associated with increased risk of patient death. The unadjusted rate of acute rejection was lower with IL-2Ra induction for intermediate-risk (P < 0.001, chi-square test), but not for low-risk recipients. In the adjusted model, the use of IL-2Ra was associated with a decrease in the RR of acute rejection at 6 months in intermediate-risk (RR 0.74, 95% CI 0.63, 0.88) but not in low-risk Kinase Inhibitor Library mw recipients (RR 1.00, 95% CI 0.71, 1.43; Tables 2,3). In low-risk recipients, donor and recipient characteristics associated with increased rejection

risk include older donors, older and male recipients, whereas for intermediate-risk recipients, older donors, obese

recipients and current smokers were associated with a greater risk of rejection. When intermediate-risk recipients were stratified according to initial CNI, IL-2Ra either was associated with reduced rejection risk in cyclosporine-treated recipients (n = 1929, adjusted RR 0.65, 95% CI 0.52, 0.81; P < 0.001) but not in tacrolimus-treated patients (n = 767, adjusted RR 0.90, 95% CI 0.68, 1.20; P = 0.48). There was no association between low-risk recipients and rejection when stratified by initial CNI (data not shown). In the unadjusted and adjusted linear regression models, there was no relationship between the use of IL-2Ra and eGFR at 1 and 5 years for both low- and intermediate-risk recipients (Table 4). For low-risk recipients, donor and recipient characteristics associated with higher eGFR at 1 and/or 5 years include live-donor transplants, younger donors and recipients, whereas for intermediate-risk recipients, live-donor transplants, male recipients, younger donor and recipient age were associated with higher eGFR at 1 and/or 5 years. In this Australian registry-based analysis, the use of IL-2Ra induction therapy was associated with reduced rejection risk in intermediate-risk recipients but this was only apparent in recipients receiving cyclosporine as initial immunosuppression. However, there was no association between IL-2Ra and other graft or patient outcomes in intermediate-risk recipients.