The Association between Human Leukocyte Antigens and Hypertensive End-Stage Renal Failure among Yemeni Patients

Objectives: Many studies have tried to uncover a hyperlink between various genetics as well as the pathogenesis of certain illnesses. A number of these have found human leukocyte antigens (HLAs) is easily the most critical genetics affecting the susceptibility of the baby with a certain disease. The present situation-control study aimed to discover the outcomes of class I and class II HLAs and instances of hypertensive finish-stage kidney failure (HESRF), as contrasted with healthy controls, in Yemen.

Methods: The study was transported out between March 2013 and March 2014 and incorporated 50 HESRF patients attending the Urology & Nephrology Center at Al-Thawra College Hospital in Sana’a, Yemen, and 50 healthy controls visiting the same center for kidney donation. Among both patients and controls, HLA class I (A, B and C) and class II (DRB1) genotypes were according to polymerase chain reactions.

Results: There’s an association (odds ratio: 4.) with HLA-A9(24) and HESRF, even if this wasn’t statistically significant. A considerable protective function is discovered for your HLA-CW3 and DRB1-8 genes against the development of HESRF. Although HLA-B14 was found in some patients (.06) and DRB18  from the controls, this difference wasn’t statistically significant enough in summary that HLA-B14 leads to the genetic predisposition for finish-stage kidney disease development. There’s a greater frequency of HLA-A2, B5, CW6, DRB1-3, DRB1-4 and DRB1-13 in patients and controls.

Conclusion: Although no HLAs come up with to get a very significant role in genetic predisposition to HESRF, certain HLA genes may be considered as protective genes against HESRF development.