(c) 2011 American Institute of Physics. [doi: 10.1063/1.3540623]“
“Thin-section computed tomography (CT) of the lungs was introduced more than 20 years ago
and has an established role in the assessment of patients who are known to have, or are suspected of having, diffuse lung disease. Thin-section CT can demonstrate very early disease, sometimes in individuals without symptoms or pulmonary function test abnormalities. Such sensitivity comes at a price because it may be difficult to distinguish thin-section CT findings that lie within the normal range from those that represent early, but important, disease. This review examines particular thin-section CT findings selleck chemical that occupy the gray area between unequivocal health and definite disease, with a particular focus on the effects of cigarette smoking and aging”
“Lead-free multiferroic particulate composites of Na0.5Bi0.5TiO3 (NBT) and CoFe2O4 (CFO) have been synthesized by solid-state sintering method. A systematic study of structural, magnetic and magnetoelectric (ME) properties is undertaken. Structural and morphology studies carried out by x-ray diffraction and field emission scanning electron microscopy indicate formation of single phase for parent phases and presence of both phases
in the composites. Magnetic properties are investigated selleck using vibrating sample magnetometer and ferromagnetic resonance (FMR) measurements at room temperature. Strong ME coupling is demonstrated in NBT-CFO 70-30 mol% composite by an electrostatically tunable FMR field shift up to 428 Oe (at E = 3.9 kV/cm), which increases to a large value of 640 Oe at E = 6.8 kV/cm. Furthermore, these lead-free multiferroic composites exhibiting electrostatically induced magnetic resonance field at microwave frequencies provide great opportunities for
electric field tunable microwave devices. (C) 2011 American Gamma-secretase inhibitor Institute of Physics. [doi:10.1063/1.3544500]“
“Background: Tyrosinase (TYR) is a Key pigmentation gene that is highly polymorphic and responsible for the most common form of autosomal recessive albinism, OCA1.
Objective: To assess the role of frequent and rare TYR variants in predisposition to skin cancer (SK) in the French population.
Methods: We genotyped a frequent TYR variant (p.R402Q) in 1273 patients (1047 cutaneous melanoma (CM) and 226 basal cell carcinoma (BCC)) and 925 controls, and the full coding region of TYR was sequenced in 287 patients suspected of genetic predisposition to SK (familial and/or multiple SK and/or onset before 40 years) and 187 controls.
Results: The homozygous p.R402Q variant was significantly associated with SK risk (P value = 0.008; OR = 1.57), and was mostly associated with multiple CM risk (P value = 0.021; OR = 2.50) and familial CM risk (P value = 0.022; OR = 2.16). In addition, 19 rare TYR variants, mainly albinism mutations, were identified in 15 patients and 8 controls.