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Authors’ oxyclozanide contribution Conceived and designed the experiments: AD, SD. Performed the experiments: AD, MC. Analyzed the data: AD, MC, SD. Wrote the paper: AD, SD. All authors read and approved the final manuscript.”
“Background In the past, E. faecium was considered to be a harmless commensal of the mammalian GI tract and was used as a probiotic in fermented foods [1, 2]. In recent decades, E. faecium has been recognised as an opportunistic pathogen that causes diseases such as neonatal meningitis, urinary tract infections, bacteremia, bacterial endocarditis and diverticulitis [3–7]. Therefore, E. faecium can penetrate and survive in many environments in the human body, which could potentially lead to unpredictable consequences. Due to revolutionary advances in high-throughput DNA sequencing technologies [8] and computer-based genetic analyses, genome decoding and transcriptome sequencing (RNA-seq) [9, 10] analyses are rapid and available at low costs.