6) 17 (51.5) 7 (41.2) 11 (55.0) Age [years; median (range)] 60.1 (27.9–83.1) 58.9 (31.4–78.4) 58.1 (27.9–70.0) 56.0 (31.4–69.9) 70.0 (65.1–83.1) 71.2 (65.1–78.4) 72.2 (70.1–83.1) 73.6 (70.2–78.4) Country of origin [n (%)]  East Asian 45 (42.5) 44 (41.9) 41 (46.1) 39 (45.9) 12 (34.3) 10 (30.3) 4 (23.5) 5 (25.0)  Caucasian 39 (36.8) 35 (33.3) 29 (32.6) 27 (31.8) 18 (51.4) 14 (42.4) 10 (58.8) 8 (40.0)  Hispanic 17 (16.0) 22 (21.0) 14 (15.7) 15 (17.6) 4 (11.4) 9 (27.3) 3 (17.6) 7 (35.0)  African 5 (4.7) 4 (3.8) 5 (5.6) 4 (4.7) 1 (2.9) 0 (0.0) 0 (0.0) 0 (0.0) Smoking status [n (%)]  Never smoked 34 (32.1) 41 (39.0) 31 (34.8) 33 (38.8) Selleck Decitabine 5 (14.3) 11 (33.3) 3 (17.6) 8 (40.0)  Ever smoked but quit 61 (57.5) 53 (50.5)

48 (53.9) 41 (48.2) 27 (77.1) 20 (60.6) 13 (76.5) 12 (60.0)  Currently smoking 11 (10.4) 11 (10.5) 10 (11.2) 11 (12.9) 3 (8.6) 2 (6.1)

1 (5.9) 0 (0.0) Pathological diagnosis [n (%)]  Adenocarcinoma 90 (84.9) 91 (86.7) 77 (86.5) 73 (85.9) 29 (82.8) 29 (87.9) 13 (76.5) 18 (90.0)  Large cell carcinoma 10 (9.4) 9 (8.6) 7 (7.9) 7 (8.2) 4 (11.4) 3 (9.1) 3 (17.6) 2 (10.0)  Lung carcinoma 6 (5.7) 5 (4.8) 4 (4.5) 5 (5.9) 2 (5.7) 1 (3.0) Rapamycin 1 (5.9) 0 (0.0) Disease stage [n (%)]  Stage IIIB 17 (16.0) 23 (21.9) 15 (16.9) 20 (23.5) 4 (11.4) 6 (18.2) 2 (11.8) 3 (15.0)  Stage IV 89 (84.0) 82 (78.1) 74 (83.1 65 (76.5) 31 (88.6) 27 (81.8) 15 (88.2) 17 (85.0) ECOG performance status [n (%)]  0 31 (29.2) 28 (26.7) 28 (31.5) 22 (25.9) 8 (22.9) 9 (27.3) 3 (17.6) 6 (30.0)  1 60 (56.6) 60 (57.1) 49 (55.1) 48 (56.5) 22 (62.9) 18 (54.5) 11 (64.7) 12 (60.0)  2 15 (14.2) 17 (16.2) 12 (13.5) 15 (17.6) 5 (14.3) 6 (18.2) 3-mercaptopyruvate sulfurtransferase 3 (17.6) 2 (10.0) Prior therapy [n (%)] 15 (14.2)

16 (15.2) 11 (12.4) 14 (16.5) 7 (20.0) 3 (9.1) 4 (23.5) 2 (10.0)  Chemotherapy 4 (3.8) 2 (1.9) 2 (2.2) 2 (2.4) 3 (8.6) 0 (0.0) 2 (11.8) 0 (0.0)  Radiotherapy 8 (7.5) 7 (6.7) 6 (6.7) 7 (8.2) 4 (11.4) 1 (3.0) 2 (11.8) 0 (0.0)  Surgery 11 (10.4) 11 (10.5) 8 (9.0) 9 (10.6) 6 (17.1) 2 (6.1) 3 (17.6) 2 (10.0) ECOG Eastern Cooperative Oncology Group, N population size, n number in group, Q-ITT qualified intent-to-treat 3.1.1 Treatment Delivery The six-cycle completion rates in the <70-, ≥65-, and ≥70-year age groups were as follows: pemetrexed + carboplatin 58.4, 57.1, and 52.9 %, respectively; docetaxel + carboplatin 44.7, 54.5, and 60.0 %, respectively.