278, 95%CI 1.002–1.629). There was no

significance finding between the selected 8 tag-SNPs and UC. Conclusion: For the first time, our results revealed that polymorphisms of IL-33 had an effect on the development of some extra-intestinal manifestation and clinical phenotypes of CD in Chinese population, which further confirmed a critical role of IL-33 in the pathogenesis of IBD. Key Word(s): 1. IL-33; 2. IBD; 3. SNP; 4. clinical phenotypes; Presenting Author: TAKESHI SATO Additional Authors: EIKI NOMURA, YU SASAKI, NANA KANNO, MAKOTO YAGI, KAZUYA YOSHIZAWA, DAISUKE IWANO, YASUHIKO ABE, SYOICHI NISHISE, YOSHIYUKI UENO Corresponding Author: TAKESHI SATO Affiliations: Yamagata University, faculty of medicine, department of gastroenterology

Objective: In Japan, Infliximab Nutlin-3a ic50 (IFX) was adopted middle to severe ulcerative colitis that indicated adequate effect by selleck chemicals llc current treatment in 2012. We have begun to apply IFX for Ulcerative colitis from July, 2010. We reported our experience of IFX, and its effectiveness. Methods: In our hospital, IFX is applied to severe and intractable case of steroid resistance, and steroid dependent. Patients intake diphenhydramine 10 mg, and injected hydrocortisone sodium succinate before intravenous drip injection IFX 5 mg/kg. Participants in this study were Dimethyl sulfoxide eleven cases of ulcerative colitis induced IFX in our hospital

from 2010 to 2012. We defined effectiveness of IFX by Clinical activity index (CAI). Remission was that CAI decreased lower than 4, improve was that CAI was lower than 10 and decrease over three points from started injection. Results: Mean age of participants was 37 years old, male were six cases, and mean disease time was 9.5 years. Pan colitis were nine cases (82%), left side colitis were two cases. All were middle ulcerative colitis. Steroid resistance ware three cases and steroid dependent were seven cases. All cases take 5-aminosalicylic acid, ten cases treated with steroid, and two cases use immunomodulatory drugs. The effective cases divided into three types of after response. (1) maintenance effectiveness, (2) attenuated effectiveness (couldn’t keep effectiveness for eight weeks), (3) lose effectiveness. Steroid required again or to increase dose in two cases, in type (1). Finally they were stopped steroid. Three cases were attenuated effectiveness, two of three were shortened injection period of IFX, but had no adequate result in type (2). Lose effectiveness cases mostly became clear at fourteen to twenty two weeks. Conclusion: In this study, we reported our experience of IFX, and its effectiveness to ulcerative colitis. We want to evaluate with more cases to superior treatment. Key Word(s): 1. ulcerative colitis; 2.