73 m(-2) (+1.5), 0.30-0.59

(+1), ankle-brachial index: <0.3 (+2), 0.3-0.49 (+1.5) and >1.3 (+2); C-reactive protein buy Vactosertib (CRP) >= 70 mg l(-1) (+2); and association of statins, anti-platelet agents and renin-angiotensin system inhibitors (-1.5). The frequency of the composite outcome increased significantly with the predicted risk: low risk (<= 0 point), 2%; medium (0.5-2 points), 12.8%; high (2.5-4 points), 23%; very high (>= 4.5 points): 42.2%. The model had a good performance in terms of discrimination (C-statistic 0.74 and 0.76) and calibration (Hosmer-Lemeshow 0.65).

Conclusions: We propose the validated COPART risk score for hospitalised severe PAD. This prognostic risk score is based on six variables easily identifiable in clinical

practice. Our study highlights the favourable prognostic impact of the prescription at discharge of combined drug therapies. (C) 2013 European Society for Vascular Surgery. Published by Elsevier Ltd. All rights reserved.”
“Background. Metabolic risk factors like QNZ insulin resistance and dyslipidemia are frequently observed in severly obese children. We investigated the hypothesis that moderate weight reduction by a low-threshold intervention is already able to reduce insulin resistance and cardiovascular risk factors in severely obese children. Methods. A group of 58 severely obese children and adolescents between 8 and 17 years participating in a six-month-long outpatient

program was studied before and after treatment. The program included behavioral treatment, dietary education and specific physical training. Metabolic parameters were measured in the fasting state, insulin resistance was evaluated in an oral glucose tolerance test. Results. Mean standard deviation score of the selleck chemicals llc body mass index (SDS-BMI) in the study group dropped significantly from +2.5 +/- 0.5 to 2.3 +/- 0.6 (P < 0.0001) after participation in the program. A significant decrease was observed in HOMA (6.3 +/- 4.2 versus 4.9 +/- 2.4, P < 0.03, and in peak insulin levels (232.7 +/- 132.4 versus 179.2 +/- 73.3 mu U/mL, P < 0.006). Significant reductions were also observed in mean levels of hemoglobin A(1c), total cholesterol and LDL cholesterol. Conclusions. These data demonstrate that already moderate weight reduction is able to decrease insulin resistance and dyslipidemia in severely obese children and adolescents.”
“Objectives: The aortic augmentation index (Alx), a marker of arterial stiffness, and peripheral arterial disease (PAD) are associated with an increased cardiovascular risk. In claudicants, the effect of balloon angioplasty (percutaneous transluminal angioplasty, PTA) on Alx has not been determined so far.