Conclusions. In this preliminary study, manipulation of the lithotripter output voltage distribution did not affect stone comminution efficiency for renal or UPJ stones. This finding should be confirmed by larger studies including more patients.”
“Purpose of review
Individuals with systemic lupus erythematosus (SLE) have an increased susceptibility to certain types of cancer.
Given concerns focused on this issue, we present a review of this important GSK3326595 topic.
Recent findings
In non-Hodgkin lymphoma (NHL), a several-fold increased risk is seen in SLE versus the general population. It has long been suspected that immunosuppressive drugs play a role in this risk, but there may be other important driving factors as well. Lupus disease activity may itself heighten the risk of lymphoma in diseases like SLE. Lung cancer risk also is increased in SLE; smoking appears to drive this risk. Additionally, cervical dysplasia risk is increased in SLE, particularly with immunosuppressive drug exposure. An altered clearance of cancer-related
viral agents in SLE (due to the disease Selleck Crenigacestat and/or immunosuppression) may contribute to this risk and may also drive the risk for other cancers (such as vulvovaginal and hepatic carcinomas) in SLE.
On the positive side, one new and significant finding is that SLE patients seem to have a decreased risk of certain nonhematologic cancers (breast, ovarian, endometrial, and prostate).
Summary
Though much has been learnt so far regarding the risk in SLE, much yet remains unknown.”
“AimThe aim of this study was
to better characterize the nature of abruptio RG-7388 inhibitor placentae (AP) with regard to the timing of onset.
Material and MethodsPrevalence and prospective risk of AP according to gestational week (GW) were determined among 293899 women who gave birth to singleton infants at and after GW 30. The prospective risk of AP at gestational week N was defined as the number of all women who experienced an AP at GW N divided by the number of all women who gave birth at GW N.
ResultsAP developed in 2649 (0.90%) women. The prevalence of AP (6.7% among women who gave birth at GW 30-33) sharply decreased with advancing GW at delivery to 0.9% for GW 37 and 0.1% for GW 42. The highest prospective risk of AP, 9 per 1000 women at GW 30, decreased linearly with advancing gestation to 1 per 1000 women at GW 42. AP accounted for 4.7% (1591/33725) of all preterm births at GW <37, while prevalence of AP was 0.41% (1058/260174) among term births. Preterm AP accounted for 60.1% (1591/2649) of all AP.
ConclusionOur figures indicate that AP is more common in preterm births than in term birth and may be helpful for better understanding the epidemiology of this condition.”
“Purpose of review
New drugs are continuously being developed and some rheumatic syndromes have been associated with specific drugs.