3552597]”
“In order to investigate the immunopharmacological function of Astragalus polysaccharide (APS) in Type 1 diabetes mellitus (T1DM), multiple low-dose streptozotocin-induced diabetic mice

and normal mice were administered either APS or saline intraperitoneally once daily. The changes in galectin-1 expression in different organs of the mice were detected by ELISA, Real-time fluorescence quantitative RT-PCR and Western click here blot. The percentages of apoptotic CD8(+) T cells from spleens of APS-treated diabetic mice were measured by flow cytometry. We found that the expression of galectin-1 was increased in serum of APS-treated diabetic mice compared to the non-treated diabetic mice (*p < 0.05). Increased galectin-1 was mainly expressed in the muscle of APS-treated mice. In vitro, APS up-regulated the expression of galectin-1 in muscle cells in a dose-dependent manner. The percentage of apoptotic CD8(+) T cells in spleens of APS-treated mice was positively correlated with the concentration of APS treatment, and the blocking of galectin-1 in vivo by specific antibody reduced the percentage

of apoptotic CD8(+) T cells in APS-treated mice. Our findings indicated that APS could up-regulate the expression of galectin-1 in muscle of T1DM mice, resulting in the apoptosis of CD8(+) T cells. This may be an important mechanism by which APS protects beta cells of the pancreatic islets from apoptosis induced by CD8(+) T cells in T1DM in vivo.”
“We report a case of cat scratch disease

with bilateral selleck inhibitor renal microabscesses. This case is unique in that there were no other abscesses found intrabdominally. A previously healthy child was admitted with a 12-day history of fever and headaches. Bartonella henselae titers were initially IgG 1:640 and IgM 1:100, and later IgG >1:2560 and IgM >1:800. An abdominal Fer-1 clinical trial ultrasound examination was normal but CT scan revealed microabscesses in both kidneys.”
“To elucidate the effects of a static electric field on the crystal growth of a molecule with both a molecular dipole and a quadrupole moment, we performed physical vapor growth of monoclinic lead phthalocyanine (PbPc) crystals under quasithermal equilibrium conditions and observed distinct effects of the applied electric field on the drift motion of the molecules that diffused over the substrate surface. The density of crystals grown on the Au electrode with a high electric potential exceeds the crystal density on both an electrically grounded electrode and a glass substrate surface. In addition, this difference in crystal density increases with applied voltage. This biased distribution of crystal growth is explained by the drift motion of diffusing molecules, which is induced by the interaction of the electric field with molecular dipole and quadrupole moments.