Development

Development Ferroptosis tumor and validation of LC-MS/MS assays for the quantification of bendamustine and its metabolites in human plasma and urine. J Chromatogr B Analyt Technol Biomed Life Sci. 2012;893–894:92–100.PubMed 18. Dubbelman AC, Rosing H, Jansen RS, et al. Mass balance study of 14C-eribulin in patients with advanced solid tumours. Drug Metab Dispos. 2012;40(2):313–21.PubMedCrossRef 19. US Department of Health and Human Services, Food and Drug Administration, Center for Drug Evaluation and Research (CDER), Center for Veterinary Medicine (CVM). Guidance for industry: bioanalytical method validation. Rockville:

CDER, 2001 May. http://​www.​fda.​gov/​downloads/​Drugs/​GuidanceComplian​ceRegulatoryInfo​rmation/​Guidances/​ucm070107.​pdf. Accessed 4 Oct 2012. 20. Owen JS, Melhem M, Passarell JA, et al. Bendamustine pharmacokinetic profile and exposure-response relationships in patients with indolent non-Hodgkin’s lymphoma. Cancer Chemother Pharmacol. 2010;66(6):1039–49.PubMedCrossRef 21. Beumer JH, Beijnen JH, Schellens JH. Mass balance studies, with a focus on anticancer drugs. Clin Pharmacokinet. 2006;45(1):33–58.PubMedCrossRef 22. Knauf WU, Lissichkov T, Aldaoud A, et al. Phase III randomized study of bendamustine compared with chlorambucil in previously untreated patients with chronic lymphocytic leukemia. J Clin Oncol. 2009;27(26):4378–84.PubMedCrossRef 23. Bagnobianchi A, Spanswick

VJ, Bingham JP, et al. Persistence Temsirolimus in vivo of drug-induced DNA interstrand cross-links distinguishes bendamustine from conventional DNA cross-linking agents [abstract no. 1766]. 103rd Annual Meeting of the American

Association for Cancer Research; 2012 Mar 31–Apr 4; Chicago. 24. Cheson BD, Wendtner C-M, Pieper A, et al. Optimal use of bendamustine in chronic lymphocytic leukemia, non-Hodgkin lymphomas, and multiple myeloma: treatment recommendations from an international consensus panel. Clin Lymphoma Myeloma Leuk. 2010;10(1):21–7.PubMedCrossRef 25. https://www.selleckchem.com/products/nutlin-3a.html Visani G, Malerba L, Stefani PM, et al. BeEAM (bendamustine, etoposide, cytarabine, melphalan) before autologous stem cell transplantation is safe and effective for resistant/relapsed lymphoma STK38 patients. Blood. 2011;118:3419–25.PubMedCrossRef 26. Dubbelman AC, Jansen RS, Rosing H, et al. Metabolite profiling of bendamustine urine of cancer patients after administration of [14C]bendamustine. Drug Metab Dispos. 2012;40(7):1297–307.PubMedCrossRef 27. Preiss R, Teichert J, Athmani A, et al. Pharmacokinetics and toxicity profile of bendamustine in patients with impaired liver function [poster]. 2nd International Conference on Drug Discovery and Therapy; 2010 Feb 1–4; Dubai. 28. Preiss R, Teichert J, Poenisch W, et al. Bendamustine pharmacokinetics and safety are not afflicted by impaired renal function in patients with multiple myeloma [abstract no. 5254]. Blood. 2003;102:381–2b.

Comments are closed.