The maximum activity of compound 3 against Lung cancer, renal cancer and Breast cancer due to presence of two methyl and –SCH3 groups in their nucleus. Compound 4-a and 4-d exhibited remarkable percentage growth inhibition
against HOP-92 (Lung cancer), UACC-62 (Melanoma), and HOP-92 (Lung cancer), UACC-62 (Melanoma) respectively due to presence of p-CH3 and p-OCH3 group. Compound 5-a exhibited excellent activity against K-562, RPMI-8226 (Leukemia), HOP-92 (Lung cancer), LY2157299 order UO-31 (Renal cancer) cell lines panel due to presence of p-Cl group. Compounds 6-a and 6-b exhibited inhibitory effect against CAKI-1, UO-31 (Renal cancer), MCF-7 (Breast cancer) and K-562 (Leukemia), CAKI-1, UO-31 (Renal cancer), PC-3 (Prostrate cancer) due to presence Selleck Quizartinib of heteryl cyclic amines at 2-positions respectively. The maximum in-vitro anticancer activity of selected compounds against Leukemia, Lung, Melanoma, CNS, Colon, Ovarian, Renal, prostate and breast cancer cell lines are due to the presence of –SCH3, electron
donating group like –CH3, –OCH3, –Cl and heterocyclic moiety at 2-position like pyrrolidine, morpholine. All authors have none to declare. Authors are thankful to National Cancer Institute (NCI), Bethesda, Maryland, (USA) for providing the in-vitro anticancer activity, and to the Director, IICT Hyderabad for providing Spectra. Authors also thankful to the Principal, Yeshwant Mahavidyalaya, Nanded for providing laboratory facilities. “
“An antioxidant is any substance that at low concentration delays the oxidation of proteins, carbohydrates, lipids and DNA. They can be classified into three main categories: 1. The first line defence antioxidants which include superoxide dismutase (SOD), catalase (CAT), glutathione reductase (GR) and minerals like Se, Cu, Zn etc. Oxidative stress is a result of an imbalance between reactive oxygen species (ROS) and antioxidant defences. This oxidative stress deregulates
a series of cellular functions and leads to various pathological conditions like AIDS, ageing, arthritis, asthma, autoimmune diseases, carcinogenesis, cardiovascular dysfunction, cataract, diabetes, neurodegenerative ever diseases, Alzheimer’s disease, Parkinson’s dementia etc.2, 3, 4, 5, 6, 7, 8 and 9 Free radicals are highly reactive species having unpaired electrons in their outermost shell. Free radicals react rapidly with the membranes eventually causing cellular degeneration and finally death. To cope with these radicals the living system produces many antioxidants or takes the supplement through diet. They occur in blood by combining with different chemicals found in polluted air and water etc. Research is going in the direction that for the neurological diseases like Parkinson’s and Alzheimer’s these free radicals are one of the causes.